Doxorubicin is an anthracycline type of chemotherapy that is used to treat several different types of cancer.
Nausea, vomiting, diarrhea, and loss of appetite may occur. Nausea and vomiting can be severe.
This product may contain inactive ingredients, which can cause allergic reactions or other problems.
Doxorubicin Hydrochloride Powder for Injection is an anthracycline type of chemotherapy that is used to treat several different types of cancer. Doxorubicin works by slowing or stopping the growth of cancer cells.
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Cancerous tumors are characterized by cell division, which is no longer controlled as it is in normal tissue. “Normal” cells stop dividing when they come into contact with like cells, a mechanism known as contact inhibition.
NCARDIOMYOPATHY, SECONDARY MALIGNANCIES, EXTRAVASATION AND TISSUE NECROSIS, and SEVERE MYELOSUPPRESSION
Cardiomyopathy: Myocardial damage, including acute left ventricular failure can occur with doxorubicin HCl. The risk of cardiomyopathy is proportional to the cumulative exposure with incidence rates from 1% - 20% for cumulative doses ranging from 300 mg/m to 500 mg/m when doxorubicin HCl is administered every 3 weeks. The risk of cardiomyopathy is further increased with concomitant cardiotoxic therapy. Assess LVEF before and regularly during and after treatment with doxorubicin HCl [see WARNINGS AND PRECAUTIONS].
Secondary Malignancies: Secondary acute myelogenous leukemia (AML) and myelodysplastic syndrome (MDS) occur at a higher incidence in patients treated with anthracyclines, including doxorubicin HCl [see WARNINGS AND PRECAUTIONS].
Extravasation and Tissue Necrosis: Extravasation of doxorubicin HCl can result in severe local tissue injury and necrosis requiring wide excision of the affected area and skin grafting. Immediately terminate the drug and apply ice to the affected area [see WARNINGS AND PRECAUTIONS].
Severe myelosuppression resulting in serious infection, septic shock, requirement for transfusions, hospitalization, and death may occur [see WARNINGS AND PRECAUTIONS].
It can also be used in the management of non-metastatic carcinoma of the bladder, where it is administered intravesically.
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